Glutamine supplementation in irritable bowel syndrome (IBS): a randomized placebo-controlled trial
Zhou Q, Verne ML, Fields JZ, Lefante JJ, Basra S, Salameh H, Verne GN, Randomised placebo-controlled trial of dietary glutamine supplements for postinfectious irritable bowel syndrome, Gut. 2018 Aug 14. pii: gutjnl-2017-315136. doi: 10.1136/gutjnl-2017-315136.
An eight-week randomized, double-blind, placebo-controlled study examined treatment with glutamine supplementation in patients with postinfectious IBS and increased intestinal permeability (leaky gut).
Participants were randomly assigned: 54 received 5 grams of glutamine, while 52 received placebo.
The results showed that, in postinfectious IBS with increased intestinal permeability, glutamine supplementation dramatically and safely reduces IBS symptoms.