{"id":16669,"date":"2024-06-23T10:55:08","date_gmt":"2024-06-23T07:55:08","guid":{"rendered":"https:\/\/marshal.co.il\/?p=16669"},"modified":"2026-10-29T00:20:47","modified_gmt":"2026-10-28T21:20:47","slug":"%d0%bf%d0%be%d0%bb%d1%8c%d0%b7%d0%b0-%d1%84%d0%be%d0%bb%d0%b8%d0%b5%d0%b2%d0%be%d0%b9-%d0%ba%d0%b8%d1%81%d0%bb%d0%be%d1%82%d1%8b-%d0%bf%d1%80%d0%b8-%d1%81%d0%b8%d0%bd%d0%b4%d1%80%d0%be%d0%bc%d0%b5","status":"publish","type":"post","link":"https:\/\/marshal.co.il\/ru\/%d0%bf%d0%be%d0%bb%d1%8c%d0%b7%d0%b0-%d1%84%d0%be%d0%bb%d0%b8%d0%b5%d0%b2%d0%be%d0%b9-%d0%ba%d0%b8%d1%81%d0%bb%d0%be%d1%82%d1%8b-%d0%bf%d1%80%d0%b8-%d1%81%d0%b8%d0%bd%d0%b4%d1%80%d0%be%d0%bc%d0%b5\/","title":{"rendered":"\u041f\u043e\u043b\u044c\u0437\u0430 \u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u043f\u0440\u0438 \u0441\u0438\u043d\u0434\u0440\u043e\u043c\u0435 \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043d\u044b\u0445 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432"},"content":{"rendered":"
By Greg Arnold, DC, CSCS, September 4, 2014, abstracted from \u201cMetabolic respons_e to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial\u201d in the July 2014 issue of Molecular Nutrition & Food Research<\/div>\n

\u0421\u0438\u043d\u0434\u0440\u043e\u043c \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043d\u044b\u0445 \u044f\u0438\u0447\u043d\u0438\u043a\u043e\u0432 \u2014 \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0451\u043d\u043d\u043e\u0435 \u0433\u043e\u0440\u043c\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0435 \u0440\u0430\u0441\u0441\u0442\u0440\u043e\u0439\u0441\u0442\u0432\u043e \u0436\u0435\u043d\u0449\u0438\u043d \u0440\u0435\u043f\u0440\u043e\u0434\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0433\u043e \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0430 \u0432\u043e \u0432\u0441\u0451\u043c \u043c\u0438\u0440\u0435, \u0437\u0430\u0442\u0440\u0430\u0433\u0438\u0432\u0430\u044e\u0449\u0435\u0435 5\u201310% (1). \u041e\u043d \u0441\u0432\u044f\u0437\u0430\u043d \u0441 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u044f\u043c\u0438 \u043c\u0435\u043d\u0441\u0442\u0440\u0443\u0430\u0446\u0438\u0439, \u0444\u0435\u0440\u0442\u0438\u043b\u044c\u043d\u043e\u0441\u0442\u0438, \u043f\u043e\u043b\u0438\u043a\u0438\u0441\u0442\u043e\u0437\u043d\u044b\u043c\u0438 \u044f\u0438\u0447\u043d\u0438\u043a\u0430\u043c\u0438, \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0435\u0439 \u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u043e\u0433\u043e \u044d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u044f \u0438 \u043f\u043e\u0432\u044b\u0448\u0435\u043d\u043d\u044b\u043c \u0434\u0430\u0432\u043b\u0435\u043d\u0438\u0435\u043c (2,3). \u0413\u043b\u0430\u0432\u043d\u0430\u044f \u043f\u0440\u0438\u0447\u0438\u043d\u0430 \u2014 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u044c (4), \u043f\u043e\u044d\u0442\u043e\u043c\u0443 \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0430\u043d\u0438\u0435 \u043d\u043e\u0440\u043c\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 \u043e\u0441\u043e\u0431\u0435\u043d\u043d\u043e \u0432\u0430\u0436\u043d\u043e. \u041d\u043e\u0432\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 (5) \u043f\u043e\u043a\u0430\u0437\u0430\u043b\u043e, \u0447\u0442\u043e \u0444\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 \u043c\u043e\u0436\u0435\u0442 \u043f\u043e\u043c\u043e\u0433\u0430\u0442\u044c.<\/p>\n

81 \u0436\u0435\u043d\u0449\u0438\u043d\u0430 \u0441 \u043e\u0436\u0438\u0440\u0435\u043d\u0438\u0435\u043c \u0432\u0435\u0441\u043e\u043c 65\u2013110 \u043a\u0433, \u0432 \u0432\u043e\u0437\u0440\u0430\u0441\u0442\u0435 18\u201340 \u043b\u0435\u0442 \u0438 \u0441 \u0434\u0438\u0430\u0433\u043d\u043e\u0437\u043e\u043c \u0421\u041f\u041a\u042f \u0435\u0436\u0435\u0434\u043d\u0435\u0432\u043d\u043e \u043f\u043e\u043b\u0443\u0447\u0430\u043b\u0430 1 \u043c\u0433 \u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b, 5 \u043c\u0433 \u0438\u043b\u0438 \u043f\u043b\u0430\u0446\u0435\u0431\u043e \u0432\u043e\u0441\u0435\u043c\u044c \u043d\u0435\u0434\u0435\u043b\u044c. \u041a\u0440\u043e\u0432\u044c \u0431\u0440\u0430\u043b\u0438 \u0434\u043e \u0438 \u043f\u043e\u0441\u043b\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f.<\/p>\n

\u0427\u0435\u0440\u0435\u0437 \u0432\u043e\u0441\u0435\u043c\u044c \u043d\u0435\u0434\u0435\u043b\u044c \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0438 \u043e\u0442\u043c\u0435\u0442\u0438\u043b\u0438 \u043d\u0435\u0441\u043a\u043e\u043b\u044c\u043a\u043e \u0437\u043d\u0430\u0447\u0438\u043c\u044b\u0445 \u0443\u043b\u0443\u0447\u0448\u0435\u043d\u0438\u0439 \u0432 \u0433\u0440\u0443\u043f\u043f\u0430\u0445 \u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u043f\u043e \u0441\u0440\u0430\u0432\u043d\u0435\u043d\u0438\u044e \u0441 \u043f\u043b\u0430\u0446\u0435\u0431\u043e:<\/p>\n\n\n\n\n\n\n\n\n\n

\n\u041f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c
\n<\/strong><\/td>\n
\n\u0424\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 1 \u043c\u0433 \u0432 \u0434\u0435\u043d\u044c: \u0434\u043e\/\u043f\u043e\u0441\u043b\u0435, % \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f
\n<\/strong><\/td>\n		\n


\n\u0424\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 5 \u043c\u0433 \u0432 \u0434\u0435\u043d\u044c
\n<\/strong>
\n
\n\u0414\u043e\/\u043f\u043e\u0441\u043b\u0435, % \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f
\n<\/strong><\/p>\n<\/td>\n


\n\u041f\u043b\u0430\u0446\u0435\u0431\u043e: \u0434\u043e\/\u043f\u043e\u0441\u043b\u0435, % \u0438\u0437\u043c\u0435\u043d\u0435\u043d\u0438\u044f
\n<\/strong><\/td>\n		\n

p-<\/span><\/em><\/strong>value<\/span><\/strong>
\n
\n(\u0443\u0440\u043e\u0432\u0435\u043d\u044c \u0432\u0435\u0440\u043e\u044f\u0442\u043d\u043e\u0441\u0442\u0438)
\n<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n\u0413\u043e\u043c\u043e\u0446\u0438\u0441\u0442\u0435\u0438\u043d\n<\/td>\n\n

14.6\/12.9<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 11,7%\n<\/p>\n<\/td>\n

17\/14.8\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 13%
\n<\/span><\/div>\n<\/td>\n
19.5\/20.5\u00a0<\/span>
\n\u0420\u043e\u0441\u0442 \u043d\u0430 5,1%\n<\/td>\n		\n

0.009<\/p>\n<\/td>\n<\/tr>\n

\n

\n\u0418\u043d\u0441\u0443\u043b\u0438\u043d
\n(micro Int.
\nUnits milliliter)<\/span><\/p>\n<\/td>\n

\n

10.0\/9.6<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 4%\n<\/p>\n<\/td>\n

\n

12.1\/10.4\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n16.6%<\/span><\/p>\n<\/td>\n

\n

12.0\/14.6\u00a0<\/span><\/p>\n

\n\u0420\u043e\u0441\u0442 \u043d\u0430 21,6%\n<\/p>\n<\/td>\n

\n

0.006<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

HOMA-IR<\/span>
\n(\u043c\u0435\u0442\u043e\u0434 \u043a\u043e\u043b\u0438\u0447\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0439 \u043e\u0446\u0435\u043d\u043a\u0438 \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u043e\u0440\u0435\u0437\u0438\u0441\u0442\u0435\u043d\u0442\u043d\u043e\u0441\u0442\u0438 \u0438 \u0444\u0443\u043d\u043a\u0446\u0438\u0438 \u0431\u0435\u0442\u0430-\u043a\u043b\u0435\u0442\u043e\u043a)\n<\/p>\n<\/td>\n

\n

2.1\/1.9\u00a0<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 9,6%\n<\/p>\n<\/td>\n

\n

2.4\/2.1\u00a0<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 12,5%\n<\/p>\n<\/td>\n

\n

2.0\/2.7\u00a0<\/span><\/p>\n

\n\u0420\u043e\u0441\u0442 \u043d\u0430 35%\n<\/p>\n<\/td>\n

\n

0.01<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Total Cholesterol<\/p>\n

(mg\/dL)<\/p>\n<\/td>\n

\n

160.1\/156.1<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430 2,5%\n<\/p>\n<\/td>\n

\n

166.6\/138.8\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n16.7%\u00a0<\/span><\/p>\n<\/td>\n

\n

161.8\/161.5<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n0.2%\u00a0<\/span><\/p>\n<\/td>\n

0.01<\/td>\n<\/tr>\n
LDL cholesterol (mg\/dL)<\/td>\n\n

88.4\/85.4<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n3.4%\u00a0<\/span><\/p>\n<\/td>\n

\n

100.4\/70.7\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n29.6%\u00a0<\/span><\/p>\n<\/td>\n

\n

98.0\/92.9\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n5.3%\u00a0<\/span><\/p>\n<\/td>\n

\n

0.007<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Total-to-HDL
\n
\n\u0421\u043e\u043e\u0442\u043d\u043e\u0448\u0435\u043d\u0438\u0435 \u0445\u043e\u043b\u0435\u0441\u0442\u0435\u0440\u0438\u043d\u0430
\n<\/span><\/p>\n<\/td>\n

\n

3.3\/3.2\u00a0<\/span><\/p>\n

\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n3.1%\u00a0<\/span><\/p>\n<\/td>\n

\n

3.8 \/3.1<\/span>
\n\u0421\u043d\u0438\u0436\u0435\u043d\u0438\u0435 \u043d\u0430
\n18.5%<\/span><\/p>\n<\/td>\n

\n

3.8\/ .9<\/span><\/p>\n

\n\u0420\u043e\u0441\u0442 \u043d\u0430
\n2.6%<\/span><\/p>\n<\/td>\n

\n

0.01<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u041e\u0431\u044a\u044f\u0441\u043d\u044f\u044f \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c \u043f\u043e\u043b\u044c\u0437\u044b, \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u0442\u0435\u043b\u0438 \u0443\u043a\u0430\u0437\u0430\u043b\u0438, \u0447\u0442\u043e \u0444\u043e\u043b\u0438\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 \u043f\u043e\u0432\u044b\u0448\u0430\u0435\u0442 \u0430\u043a\u0442\u0438\u0432\u0430\u0446\u0438\u044e \u0410\u041c\u0424-\u0430\u043a\u0442\u0438\u0432\u0438\u0440\u0443\u0435\u043c\u043e\u0439 \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043a\u0438\u043d\u0430\u0437\u044b \u2014 \u0444\u0435\u0440\u043c\u0435\u043d\u0442\u0430, \u0443\u043b\u0443\u0447\u0448\u0430\u044e\u0449\u0435\u0433\u043e \u0444\u0443\u043d\u043a\u0446\u0438\u044e \u0438\u043d\u0441\u0443\u043b\u0438\u043d\u0430 (6). \u041e\u043d\u0438 \u0437\u0430\u043a\u043b\u044e\u0447\u0438\u043b\u0438, \u0447\u0442\u043e \u00ab\u043f\u0440\u0438\u0451\u043c 5 \u043c\u0433 \u0444\u043e\u043b\u0438\u0435\u0432\u043e\u0439 \u043a\u0438\u0441\u043b\u043e\u0442\u044b \u0432 \u0434\u0435\u043d\u044c \u0432\u043e\u0441\u0435\u043c\u044c \u043d\u0435\u0434\u0435\u043b\u044c \u0443 \u0436\u0435\u043d\u0449\u0438\u043d \u0441 \u0421\u041f\u041a\u042f \u0431\u043b\u0430\u0433\u043e\u043f\u0440\u0438\u044f\u0442\u043d\u043e \u0432\u043b\u0438\u044f\u0435\u0442 \u043d\u0430 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043f\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u0438\u00bb.<\/p>\n

\n

\n

 <\/p>\n

Reference:<\/p>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0Costello, M.-F., Shrestha, B., Eden, J., Johnson, N.-P. et al., Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review.\u00a0Hum. Reprod.\u00a02007, 22, 1200\u2013 1209.<\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0Brown, M.-A., Chang, R.-J., Polycystic ovary syndrome: clinical and imaging features.\u00a0Ultrasound Q.\u00a02007, 23, 233\u2013238.<\/p>\n

3.\u00a0\u00a0\u00a0\u00a0\u00a0Dumesic, D.-A., Abbott, D.-H., Padmanabhan, V., Polycystic ovary syndrome and its developmental origins.\u00a0Rev. Endocr. Metab. Disord.\u00a02007, 8, 127\u2013141<\/p>\n

4.\u00a0\u00a0\u00a0\u00a0\u00a0Yilmaz, M., Biri, A., Bukan, N., Karakoc, A. et al., Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome.\u00a0Gynecol. Endocrinol.\u00a02005, 20, 258\u2013263<\/p>\n

5.\u00a0\u00a0\u00a0\u00a0\u00a0Asemi Z.\u00a0Metabolic respons_e to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.\u00a0Mol Nutr Food Res\u00a02014 Jul;58(7):1465-73. doi: 10.1002\/mnfr.201400033. Epub 2014 May 15<\/p>\n

6.\u00a0\u00a0\u00a0\u00a0\u00a0Buettner, R., Bettermann, I., Hechtl, C., Gabele, E. et al., Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome.\u00a0Horm. Metab. Res.\u00a02010; 42: 769\u2013774<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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