Abstracted by Tatjana Djakovic,M.S., from \u201cUndenatured Type II collagen (UC-II) for Joint Support: A Randomized, double-blind, placebo-controlled study in healthy volunteers\u201c in the October, 2013 issue of Journal of the International Society of Sports Nutrition\n<\/p>\n
Rheumatoid arthritis and other rheumatic conditions are a growing concern worldwide. Physician-diagnosed arthritis affects more than 21% of US adults, or 46.4 million people (1). Nonsteroidal anti-inflammatory drugs are often recommended for joint pain, but frequently have severe adverse effects involving kidney function, blood pressure, liver injury, increased bleeding and digestive problems including ulcers (2).<\/p>\n
Seeking alternatives, researchers found collagen may improve joint function. It is the most abundant protein in joint cartilage. Extensive cross-links between collagen proteins give joints strength and flexibility. Arthritis damages cartilage, and researchers hypothesized that replacing it would improve function. Time until joint pain during an intense stair-climbing test, average knee-joint stretching and extension measured in degrees, and the number reporting no pain after 90 days.<\/p>\n \nPlacebo \nTime until pain onset (minutes)\n<\/p>\n<\/td>\n \nParticipants reporting no pain after 90 days\n<\/p>\n<\/td>\n 1. Joint function improved significantly. Type II collagen supports joint flexibility, as demonstrated through increased knee extension. It is safe for human use and provides an effective way to improve flexibility and reduce pain (4). Research in patients diagnosed with arthritis is also important to determine whether collagen relieves pain and improves flexibility in them.<\/p>\n 1.\u00a0\u00a0\u00a0 1.\u00a0 Lawrence, Reva C., et al. “Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part II.” Arthritis & Rheumatism 58.1 (2008): 26-35.<\/p>\n 2.\u00a0\u00a0\u00a0 2.\u00a0 Ong, C. K. S., et al. “An evidence-based update on nonsteroidal anti-inflammatory drugs.” Clinical medicine & research 5.1 (2007): 19-34.<\/p>\n 3.\u00a0\u00a0 3. \u00a0\u00a0 Eyre, David. “Collagen of articular cartilage.” Arthritis research 4.1 (2002): 30-35.<\/p>\n 4.\u00a0\u00a0\u00a0\u00a0 4. Udani, Jay., et al. \u201cUndenatured Type II collagen (UC-II) for Joint Support: A Randomized, double-blind, placebo-controlled study in healthy volunteers.\u201dJournal of the International Society of Sports Nutrition (2013), 10:48.<\/p>\n","protected":false},"excerpt":{"rendered":" Abstracted by Tatjana Djakovic,M.S., from \u201cUndenatured Type II collagen (UC-II) for Joint Support: A Randomized, double-blind, placebo-controlled study in healthy<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[727],"tags":[],"class_list":["post-16713","post","type-post","status-publish","format-standard","hentry","category-727"],"acf":[],"yoast_head":"\n
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\nA recent randomized study
\n<\/strong>
\n, double-blind and placebo-controlled, included 55 participants with exercise-related joint discomfort and no history of rheumatic disease. They received 40 mg daily of type II collagen, the most common joint protein, derived from chicken sternum. Knee function after exertion was followed for 120 days. Strenuous exercise is known to be capable of causing rheumatic disease (4).<\/p>\n
\nResearchers used several measures of knee function:
\n<\/strong><\/h2>\n\n\n
\n <\/td>\n
\nCollagen
\n<\/span>
\n(n = 27)<\/td>\n\n
\n(n = 28)<\/span><\/p>\n<\/td>\n\nPercentage change\n<\/td>\n P-value<\/td>\n<\/tr>\n \n
\nAverage knee extension (degrees) after 120 days
\n<\/span><\/td>\n\nBaseline- 73.2\n<\/td>\n \nBaseline- 71\n<\/td>\n \nCollagen- 10.2%\n<\/td>\n P=0.011<\/td>\n<\/tr>\n \n \nAfter 120 days- 81.5\n<\/td>\n \nAfter 120 days- 74.5\n<\/td>\n \nPlacebo- 4.92%\n<\/td>\n<\/tr>\n \n \n \nBaseline- 1.4\n<\/td>\n \nBaseline- 1.3\n<\/td>\n \nCollagen- 50%\n<\/td>\n P=0.019<\/td>\n<\/tr>\n \n \nAfter 120 days- 2.8\n<\/td>\n \nAfter 120 days- 1.7\n<\/td>\n \nPlacebo- 23.6%\n<\/td>\n<\/tr>\n \n \n 5<\/td>\n 1<\/td>\n 80%<\/td>\n P less than or equal to 0.05<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \n
\nResults showed that in the type II collagen group:
\n<\/strong><\/h2>\n
\n2. More people experienced no pain than among those not taking the supplement.<\/p>\nReferences:<\/strong><\/h2>\n