{"id":16665,"date":"2024-06-23T10:55:08","date_gmt":"2024-06-23T07:55:08","guid":{"rendered":"https:\/\/marshal.co.il\/?p=16665"},"modified":"2026-10-29T00:20:47","modified_gmt":"2026-10-28T21:20:47","slug":"benefits-of-folic-acid-in-polycystic-ovary-syndrome","status":"publish","type":"post","link":"https:\/\/marshal.co.il\/en\/benefits-of-folic-acid-in-polycystic-ovary-syndrome\/","title":{"rendered":"Benefits of folic acid in polycystic ovary syndrome"},"content":{"rendered":"
By Greg Arnold, DC, CSCS, September 4, 2014, abstracted from \u201cMetabolic respons_e to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial\u201d in the July 2014 issue of Molecular Nutrition & Food Research<\/div>\n

Polycystic ovary syndrome is a common hormonal disorder in women of reproductive age worldwide, affecting 5\u201310% (1). It is associated with menstrual disorders, fertility problems, polycystic ovaries, vascular endothelial dysfunction and high blood pressure (2,3). Insulin resistance is its main cause (4), making maintenance of normal insulin levels a high priority. A new study (5) showed that folic acid may help.<\/p>\n

Eighty-one obese women weighing 65\u2013110 kg, aged 18\u201340 and diagnosed with PCOS, received 1 mg folic acid, 5 mg folic acid or placebo daily for eight weeks. Blood samples were taken before and after.<\/p>\n

After eight weeks, researchers noted several significant improvements in the folic acid groups compared with placebo:<\/p>\n\n\n\n\n\n\n\n\n\n

\nMeasure
\n<\/strong><\/td>\n
\nFolic acid 1 mg daily: before\/after, % change
\n<\/strong><\/td>\n		\n


\nFolic acid 5 mg daily
\n<\/strong>
\n
\nBefore\/after, % change
\n<\/strong><\/p>\n<\/td>\n


\nPlacebo: before\/after, % change
\n<\/strong><\/td>\n		\n

p-<\/span><\/em><\/strong>value<\/span><\/strong>
\n
\n(probability level)
\n<\/strong><\/p>\n<\/td>\n<\/tr>\n

\nHomocysteine\n<\/td>\n\n

14.6\/12.9<\/span>
\n11.7% decrease\n<\/p>\n<\/td>\n

17\/14.8\u00a0<\/span><\/p>\n

\n13% decrease
\n<\/span><\/div>\n<\/td>\n
19.5\/20.5\u00a0<\/span>
\n5.1% increase\n<\/td>\n		\n

0.009<\/p>\n<\/td>\n<\/tr>\n

\n

\nInsulin
\n(micro Int.
\nUnits milliliter)<\/span><\/p>\n<\/td>\n

\n

10.0\/9.6<\/span>
\n4% decrease\n<\/p>\n<\/td>\n

\n

12.1\/10.4\u00a0<\/span><\/p>\n

\nDecrease of
\n16.6%<\/span><\/p>\n<\/td>\n

\n

12.0\/14.6\u00a0<\/span><\/p>\n

\n21.6% increase\n<\/p>\n<\/td>\n

\n

0.006<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

HOMA-IR<\/span>
\n(a method used to quantify insulin resistance and beta-cell function)\n<\/p>\n<\/td>\n

\n

2.1\/1.9\u00a0<\/span>
\n9.6% decrease\n<\/p>\n<\/td>\n

\n

2.4\/2.1\u00a0<\/span>
\n12.5% decrease\n<\/p>\n<\/td>\n

\n

2.0\/2.7\u00a0<\/span><\/p>\n

\n35% increase\n<\/p>\n<\/td>\n

\n

0.01<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Total Cholesterol<\/p>\n

(mg\/dL)<\/p>\n<\/td>\n

\n

160.1\/156.1<\/span>
\n2.5% decrease\n<\/p>\n<\/td>\n

\n

166.6\/138.8\u00a0<\/span><\/p>\n

\nDecrease of
\n16.7%\u00a0<\/span><\/p>\n<\/td>\n

\n

161.8\/161.5<\/span><\/p>\n

\nDecrease of
\n0.2%\u00a0<\/span><\/p>\n<\/td>\n

0.01<\/td>\n<\/tr>\n
LDL cholesterol (mg\/dL)<\/td>\n\n

88.4\/85.4<\/span><\/p>\n

\nDecrease of
\n3.4%\u00a0<\/span><\/p>\n<\/td>\n

\n

100.4\/70.7\u00a0<\/span><\/p>\n

\nDecrease of
\n29.6%\u00a0<\/span><\/p>\n<\/td>\n

\n

98.0\/92.9\u00a0<\/span><\/p>\n

\nDecrease of
\n5.3%\u00a0<\/span><\/p>\n<\/td>\n

\n

0.007<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

Total-to-HDL
\n
\nCholesterol ratio
\n<\/span><\/p>\n<\/td>\n

\n

3.3\/3.2\u00a0<\/span><\/p>\n

\nDecrease of
\n3.1%\u00a0<\/span><\/p>\n<\/td>\n

\n

3.8 \/3.1<\/span>
\nDecrease of
\n18.5%<\/span><\/p>\n<\/td>\n

\n

3.8\/ .9<\/span><\/p>\n

\nIncrease of
\n2.6%<\/span><\/p>\n<\/td>\n

\n

0.01<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Asked how folic acid produces these benefits, the researchers explained that it increases activation of AMP-activated protein kinase, an enzyme that improves insulin function (6). They concluded that \u201c5 mg of folic acid daily for eight weeks in women with PCOS has beneficial effects on metabolic profiles.\u201d<\/p>\n

\n

\n

 <\/p>\n

Reference:<\/p>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0Costello, M.-F., Shrestha, B., Eden, J., Johnson, N.-P. et al., Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review.\u00a0Hum. Reprod.\u00a02007, 22, 1200\u2013 1209.<\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0Brown, M.-A., Chang, R.-J., Polycystic ovary syndrome: clinical and imaging features.\u00a0Ultrasound Q.\u00a02007, 23, 233\u2013238.<\/p>\n

3.\u00a0\u00a0\u00a0\u00a0\u00a0Dumesic, D.-A., Abbott, D.-H., Padmanabhan, V., Polycystic ovary syndrome and its developmental origins.\u00a0Rev. Endocr. Metab. Disord.\u00a02007, 8, 127\u2013141<\/p>\n

4.\u00a0\u00a0\u00a0\u00a0\u00a0Yilmaz, M., Biri, A., Bukan, N., Karakoc, A. et al., Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome.\u00a0Gynecol. Endocrinol.\u00a02005, 20, 258\u2013263<\/p>\n

5.\u00a0\u00a0\u00a0\u00a0\u00a0Asemi Z.\u00a0Metabolic respons_e to folate supplementation in overweight women with polycystic ovary syndrome: a randomized double-blind placebo-controlled clinical trial.\u00a0Mol Nutr Food Res\u00a02014 Jul;58(7):1465-73. doi: 10.1002\/mnfr.201400033. Epub 2014 May 15<\/p>\n

6.\u00a0\u00a0\u00a0\u00a0\u00a0Buettner, R., Bettermann, I., Hechtl, C., Gabele, E. et al., Dietary folic acid activates AMPK and improves insulin resistance and hepatic inflammation in dietary rodent models of the metabolic syndrome.\u00a0Horm. Metab. Res.\u00a02010; 42: 769\u2013774<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

By Greg Arnold, DC, CSCS, September 4, 2014, abstracted from \u201cMetabolic respons_e to folate supplementation in overweight women with polycystic<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[739,727],"tags":[],"class_list":["post-16665","post","type-post","status-publish","format-standard","hentry","category-739","category-727"],"acf":[],"yoast_head":"\nBenefits of folic acid in polycystic ovary syndrome - Marshal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/marshal.co.il\/en\/benefits-of-folic-acid-in-polycystic-ovary-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Benefits of folic acid 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