{"id":16659,"date":"2024-06-23T10:42:00","date_gmt":"2024-06-23T07:42:00","guid":{"rendered":"https:\/\/marshal.co.il\/?p=16659"},"modified":"2026-10-29T00:19:19","modified_gmt":"2026-10-28T21:19:19","slug":"grapefruit-juice-improves-coq10-absorption","status":"publish","type":"post","link":"https:\/\/marshal.co.il\/en\/grapefruit-juice-improves-coq10-absorption\/","title":{"rendered":"Grapefruit juice improves CoQ10 absorption"},"content":{"rendered":"

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2\u201d in the May 15, 2010 issue of Food Chemistry\n<\/p>\n

CoQ10<\/span>
\nwas first identified in 1957. Since then, growing scientific evidence has highlighted its importance for health. It occurs in every body tissue, especially the heart, liver, kidneys and pancreas. Its many roles include supporting healthy inflammation levels, normal mental function, heart health and normal blood sugar (2\u20137). It is also a powerful antioxidant and plays an important part in cellular energy production.\n<\/div>\n
<\/div>\n
\nDespite these health benefits, one of the main problems with
\nCoQ10<\/span>
\nis its low bioavailability, meaning poor intestinal absorption (8). This requires combining
\nCoQ10<\/span>
\nsupplements with fat-containing components to support absorption (9). A new laboratory study found that grapefruit juice may improve the uptake of
\nCoQ10<\/span><\/div>\n
\nResearchers found that cells incubated for two hours in a solution containing 1% grapefruit juice absorbed 50% more of the compound than placebo-group cells. Grapefruit juice therefore significantly increased its uptake.\n<\/div>\n
\nThe researchers suggested that grapefruit juice increases uptake of
\nCoQ10<\/span>
\nby reducing the activity of the protein
\nP-glycoprotein<\/span>
\n, which directly controls uptake of
\nCoQ10<\/span>
\ninto cells.\n<\/div>\n
\nGrapefruit juice affects absorption of prescription medicines, including medicines for blood pressure, high cholesterol and heart rhythm, requiring awareness and appropriate action. Taking prescription medication? Inform your treating physician if you wish to add grapefruit juice to your diet.<\/p>\n
References:<\/strong><\/div>\n
1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u201cQuestions and answers about Coenzyme Q10\u201d posted on the National Cancer Institute Website\u00a0http:\/\/www.cancer.gov\/cancertopics\/pdq\/cam\/coenzymeQ10\/Patient\/page2<\/a>
\n2. Wang, X.L., et al., Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons.\u00a0Am J Clin Nutr<\/em>, 2004. 80(3): p. 649-55
\n3. Ishrat T. \u00a0Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. \u00a0Printed online in\u00a0Behavioural Brain Research<\/em>\u00a0doi:10.1016\/j.bbr.2006.03.009
\n4. Hargreaves IP. \u00a0The coenzyme Q10 status of the brain regions of Parkinson\u2019s disease patients. \u00a0Neuroscience Letters<\/em>\u00a0447 (2008) 17\u201319
\n5. Pothmann, R. \u00a0Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. \u00a0Headache<\/em>\u00a02005; 45(3): 196-203
\n6. Wisloff, U., S. M. Najjar, et al. (2005). “Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.”\u00a0Science<\/em>\u00a0307(5708): 418-20
\n7. Petersen, K. F., D. Befroy, et al. (2003). “Mitochondrial dysfunction in the elderly: possible role in insulin resistance.”\u00a0Science<\/em>\u00a0300(5622): 1140-2
\n8. Y. Zhang, F. Aberg, E.L. Appelkvist, G. Dallner and L. Ernster, Uptake of dietary coenzyme Q supplement is limited in rats,\u00a0Journal of Nutrition<\/em>\u00a0125 (1995), pp. 446\u2013453
\n9. \u201cCoQ10 Emulsions Boost Bioavailability\u201d posted on Nutraingredients.com \u2013 April 8, \u00a02008\u00a0http:\/\/www.nutraingredients.com\/Research\/CoQ10-emulsions-boost-bioavailability-study<\/a>
\n10. Itagaki S. \u00a0Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2. \u00a0Food Chemistry<\/em>\u00a02010; 120(2): 552-555
\n11. A. Dahan and G.L. Amidon, Grapefruit juice and its constituents augment colchicine intestinal absorption: Potential hazardous interaction and the role of p-glycoprotein,\u00a0Pharmaceutical Research<\/em>\u00a026 (2009), pp. 883\u2013892
\n12. Itagaki S. \u00a0Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein,\u00a0Journal of Agricultural and Food Chemistry<\/em>\u00a056 (2008), pp. 6923\u20136927<\/span><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2\u201d in the May 15, 2010 issue<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[727],"tags":[],"class_list":["post-16659","post","type-post","status-publish","format-standard","hentry","category-727"],"acf":[],"yoast_head":"\nGrapefruit juice improves CoQ10 absorption - Marshal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/marshal.co.il\/en\/grapefruit-juice-improves-coq10-absorption\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Grapefruit juice improves CoQ10 absorption - Marshal\" \/>\n<meta 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