{"id":16820,"date":"2024-06-23T10:46:55","date_gmt":"2024-06-23T07:46:55","guid":{"rendered":"https:\/\/marshal.co.il\/?p=16820"},"modified":"2026-10-29T00:59:28","modified_gmt":"2026-10-28T21:59:28","slug":"%d8%a7%d9%84%d8%b1%d9%8a%d8%b3%d9%81%d9%8a%d8%b1%d8%a7%d8%aa%d8%b1%d9%88%d9%84-%d9%85%d8%a7%d8%b0%d8%a7-%d8%aa%d9%8f%d8%b8%d9%87%d8%b1-%d8%a7%d9%84%d8%af%d8%b1%d8%a7%d8%b3%d8%a7%d8%aa%d8%9f","status":"publish","type":"post","link":"https:\/\/marshal.co.il\/ar\/%d8%a7%d9%84%d8%b1%d9%8a%d8%b3%d9%81%d9%8a%d8%b1%d8%a7%d8%aa%d8%b1%d9%88%d9%84-%d9%85%d8%a7%d8%b0%d8%a7-%d8%aa%d9%8f%d8%b8%d9%87%d8%b1-%d8%a7%d9%84%d8%af%d8%b1%d8%a7%d8%b3%d8%a7%d8%aa%d8%9f\/","title":{"rendered":"\u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644: \u0645\u0627\u0630\u0627 \u062a\u064f\u0638\u0647\u0631 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a\u061f"},"content":{"rendered":"

\u0628\u0642\u0644\u0645 Gene Bruno\u060c MS\u060c MHS\u060c \u0639\u0645\u064a\u062f Huntington College of Health Sciences\u060c www.hchs.edu
\n\u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644 \u0645\u0643\u0648\u0646 \u0637\u0628\u064a\u0639\u064a \u0641\u064a \u0646\u0628\u0627\u062a\u0627\u062a \u0645\u0646\u0647\u0627 \u0627\u0644\u0639\u0646\u0628 \u0648\u0627\u0644\u0641\u0648\u0644 \u0627\u0644\u0633\u0648\u062f\u0627\u0646\u064a \u0648\u0627\u0644\u0628\u064e\u0637\u0652\u0628\u0627\u0637 \u0627\u0644\u064a\u0627\u0628\u0627\u0646\u064a (Polygonum cuspidatum) (1). \u0628\u0631\u0632 \u0641\u064a \u0633\u0648\u0642 \u0627\u0644\u0645\u0643\u0645\u0644\u0627\u062a \u0644\u0639\u0644\u0627\u0642\u062a\u0647\u060c \u0645\u0639 \u0628\u0648\u0644\u064a\u0641\u064a\u0646\u0648\u0644\u0627\u062a \u0627\u0644\u0646\u0628\u064a\u0630 \u0627\u0644\u0623\u062d\u0645\u0631 \u0627\u0644\u0623\u062e\u0631\u0649\u060c \u0628\u0640\u00ab\u0627\u0644\u0645\u0641\u0627\u0631\u0642\u0629 \u0627\u0644\u0641\u0631\u0646\u0633\u064a\u0629\u00bb: \u0627\u0646\u062e\u0641\u0627\u0636 \u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629 \u0631\u063a\u0645 \u0627\u0644\u063a\u0630\u0627\u0621 \u0627\u0644\u063a\u0646\u064a \u0628\u0627\u0644\u062f\u0647\u0648\u0646 (3). \u0648\u0627\u0632\u062f\u0627\u062f \u0627\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0628\u0647 \u0645\u0639 \u0623\u0628\u062d\u0627\u062b \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0646\u0634\u0627\u0637 \u0645\u0636\u0627\u062f \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u0648\u0627\u0644\u0633\u0631\u0637\u0627\u0646 \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0648\u0627\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0648\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629. \u0643\u0645\u0627 \u064a\u0635\u0641 \u0627\u0644\u0645\u0635\u062f\u0631 \u0645\u0644\u0627\u062d\u0638\u0629 \u0627\u0646\u062e\u0641\u0627\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648\u062a\u062d\u0633\u0646 \u0627\u0644\u0623\u062f\u0627\u0621 \u0627\u0644\u0631\u064a\u0627\u0636\u064a \u0644\u062f\u0649 \u0645\u0633\u062a\u062e\u062f\u0645\u064a\u0647.<\/p>\n


\n\u0635\u062d\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0623\u0648\u0639\u064a\u0629
\n<\/u><\/strong><\/h2>\n

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\n\u062e\u0635\u0627\u0626\u0635 \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629
\n<\/u><\/strong><\/h2>\n

\u0623\u0638\u0647\u0631\u062a \u0623\u0628\u062d\u0627\u062b \u062d\u064a\u0648\u0627\u0646\u064a\u0629 \u0646\u0634\u0627\u0637\u0627\u064b \u0645\u0636\u0627\u062f\u0627\u064b \u0644\u0644\u0623\u0643\u0633\u062f\u0629 (8)\u060c \u0644\u0643\u0646 \u0644\u0627 \u064a\u062a\u0636\u062d \u0625\u0646 \u0643\u0627\u0646 \u0645\u0628\u0627\u0634\u0631\u0627\u064b \u0623\u0645 \u0646\u0627\u062a\u062c\u0627\u064b \u0639\u0646 \u0632\u064a\u0627\u062f\u0629 \u0625\u0646\u062a\u0627\u062c \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0623\u0643\u0633\u062f\u0629. \u0648\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0629 \u0645\u062e\u0628\u0631\u064a\u0629 \u0645\u0646\u0639 \u0623\u0643\u0633\u062f\u0629 LDL \u00ab\u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0627\u0644\u0633\u064a\u0626\u00bb \u0628\u0631\u0628\u0637 \u0627\u0644\u0645\u0639\u0627\u062f\u0646 \u0648\u062a\u0642\u0644\u064a\u0644 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062c\u0630\u0648\u0631 \u0627\u0644\u062d\u0631\u0629 (9).<\/p>\n


\n\u0646\u0634\u0627\u0637 \u0645\u0636\u0627\u062f \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628
\n<\/u><\/strong><\/h2>\n

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\n\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0633\u0631\u0637\u0627\u0646
\n<\/u><\/strong><\/h2>\n

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\n\u0646\u0634\u0627\u0637 \u0645\u0636\u0627\u062f \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a
\n<\/u><\/strong><\/h2>\n

\u0623\u0638\u0647\u0631 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644 \u0646\u0634\u0627\u0637\u0627\u064b \u0645\u0636\u0627\u062f\u0627\u064b \u0644\u0644\u0641\u064a\u0631\u0648\u0633\u0627\u062a \u0645\u062e\u0628\u0631\u064a\u0627\u064b\u061b \u0641\u0645\u0646\u0639 \u0646\u0642\u0644 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u0639\u064a\u0646\u0629 \u0644\u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0625\u0646\u0641\u0644\u0648\u0646\u0632\u0627 \u0648\u062d\u062f\u0651 \u0645\u0646 \u062a\u0643\u0627\u062b\u0631\u0647 (24). \u0648\u0643\u0628\u062d \u062a\u0641\u0639\u064a\u0644 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0641\u064a\u0631\u0648\u0633 \u0627\u0644\u0647\u0631\u0628\u0633 \u0627\u0644\u0628\u0633\u064a\u0637 \u0648\u062e\u0641\u0636 \u0625\u0646\u062a\u0627\u062c DNA \u0627\u0644\u0641\u064a\u0631\u0648\u0633\u064a (25)\u060c \u0648\u0639\u0632\u0632 \u0641\u0639\u0627\u0644\u064a\u0629 \u0628\u0639\u0636 \u0627\u0644\u0639\u0644\u0627\u062c\u0627\u062a \u0627\u0644\u062f\u0648\u0627\u0626\u064a\u0629 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0625\u064a\u062f\u0632 (26).<\/p>\n


\n\u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629
\n<\/u><\/strong><\/h2>\n

\u0623\u0638\u0647\u0631\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u0625\u0637\u0627\u0644\u0629 \u0645\u0647\u0645\u0629 \u0644\u0644\u0639\u0645\u0631 \u0641\u064a \u0643\u0627\u0626\u0646\u0627\u062a \u0628\u0633\u064a\u0637\u0629 \u0643\u0627\u0644\u062e\u0645\u064a\u0631\u0629 (Saccharomyces cerevisiae) (27) \u0648\u0627\u0644\u062f\u064a\u062f\u0627\u0646 (Caenorhabditis elegans) \u0648\u0630\u0628\u0627\u0628 \u0627\u0644\u0641\u0627\u0643\u0647\u0629 (Drosophila melanogaster). \u0648\u0623\u064f\u0628\u0644\u063a \u0639\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0645\u0634\u0627\u0628\u0647\u0629 \u0641\u064a \u0623\u0633\u0645\u0627\u0643 \u0642\u0635\u064a\u0631\u0629 \u0627\u0644\u0639\u0645\u0631\u060c \u0645\u0639 \u062a\u062d\u0633\u0646 \u0627\u0644\u0625\u062f\u0631\u0627\u0643 \u0648\u0627\u0644\u0623\u062f\u0627\u0621 \u0643\u0627\u0644\u0633\u0628\u0627\u062d\u0629. \u0648\u0648\u062c\u062f\u062a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u062a\u062d\u0633\u0646 \u0627\u0644\u0628\u0642\u0627\u0621 \u0648\u0627\u0644\u0635\u062d\u0629 \u0641\u064a \u0641\u0626\u0631\u0627\u0646 \u0639\u0644\u0649 \u063a\u0630\u0627\u0621 \u0639\u0627\u0644\u064a \u0627\u0644\u0633\u0639\u0631\u0627\u062a (30). \u0648\u064a\u0630\u0643\u0631 \u0627\u0644\u0645\u0635\u062f\u0631 \u0623\u0646 \u0622\u0644\u064a\u0629 \u062a\u0623\u062b\u064a\u0631\u0647 \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0644\u0623\u0643\u0633\u062f\u0629 \u063a\u064a\u0631 \u0645\u0639\u0631\u0648\u0641\u0629\u060c \u0644\u0643\u0646\u0647\u0627 \u0642\u062f \u062a\u0631\u062a\u0628\u0637 \u0628\u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u064a\u0646 SIR2.<\/p>\n


\n\u0625\u0645\u0643\u0627\u0646\u0627\u062a \u062e\u0641\u0636 \u0627\u0644\u0648\u0632\u0646 \u0648\u0627\u0644\u0623\u062f\u0627\u0621 \u0627\u0644\u0631\u064a\u0627\u0636\u064a
\n<\/u><\/strong><\/h2>\n

\u0639\u0644\u0649 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u062e\u0644\u0648\u064a \u062a\u062a\u0636\u0645\u0646 \u0627\u0644\u0633\u0645\u0646\u0629 \u0632\u064a\u0627\u062f\u0629 \u0639\u062f\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0648\u062d\u062c\u0645\u0647\u0627\u060c \u0648\u0647\u064a \u062a\u062a\u0637\u0648\u0631 \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0642\u0628\u0644 \u062f\u0647\u0646\u064a\u0629 \u0641\u064a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u062f\u0647\u0646\u064a. \u0648\u062b\u0628\u062a \u0623\u0646 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644 \u064a\u062b\u0628\u0637 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0642\u0628\u0644 \u0627\u0644\u062f\u0647\u0646\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0627\u0639\u062f \u0639\u0644\u0649 \u062a\u0642\u0644\u064a\u0644 \u062a\u0643\u0648\u0651\u0646 \u062e\u0644\u0627\u064a\u0627 \u062f\u0647\u0646\u064a\u0629 \u062c\u062f\u064a\u062f\u0629.
\n\u064a\u0646\u062a\u062c \u062c\u064a\u0646 SIR2 \u0644\u062f\u0649 \u0627\u0644\u062d\u064a\u0648\u0627\u0646 \u0648\u0627\u0644\u0625\u0646\u0633\u0627\u0646 \u0628\u0631\u0648\u062a\u064a\u0646 \u0633\u064a\u0631\u062a\u0648\u064a\u0646 1\u060c \u0623\u0648 SIRT1\u060c \u0627\u0644\u0630\u064a \u064a\u0633\u0647\u0645 \u0641\u064a \u062a\u0639\u0628\u0626\u0629 \u0627\u0644\u062f\u0647\u0648\u0646 \u0641\u064a \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u062f\u0647\u0646\u064a. \u0648\u064a\u0646\u0634\u0637\u0647 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644. \u0648\u0623\u0638\u0647\u0631\u062a \u0623\u0628\u062d\u0627\u062b \u0639\u0644\u0649 \u0627\u0644\u0641\u0626\u0631\u0627\u0646 \u062a\u0623\u062b\u064a\u0631\u0627\u064b \u0636\u062f \u0627\u0644\u0633\u0645\u0646\u0629 \u0648\u062a\u062d\u0633\u0646\u0627\u064b \u0641\u064a \u0645\u0642\u0627\u0648\u0645\u0629 \u0627\u0644\u0625\u0646\u0633\u0648\u0644\u064a\u0646 (33)\u060c \u0648\u062a\u062d\u0633\u0646\u0627\u064b \u0641\u064a \u0636\u0628\u0637 \u0633\u0643\u0631 \u0627\u0644\u062f\u0645 \u0628\u062a\u0646\u0634\u064a\u0637 SIRT1 (34). \u0648\u064a\u0628\u0642\u0649 \u062d\u062f\u0648\u062b \u062a\u0623\u062b\u064a\u0631 \u0645\u0645\u0627\u062b\u0644 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631 \u0633\u0624\u0627\u0644\u0627\u064b \u064a\u062d\u062a\u0627\u062c \u0628\u062d\u062b\u0627\u064b \u0625\u0636\u0627\u0641\u064a\u0627\u064b. \u0648\u064a\u0638\u0644 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644 \u0645\u0627\u062f\u0629 \u0637\u0628\u064a\u0639\u064a\u0629 \u0645\u062b\u064a\u0631\u0629 \u0644\u0644\u0627\u0647\u062a\u0645\u0627\u0645 \u0630\u0627\u062a \u0625\u0645\u0643\u0627\u0646\u0627\u062a \u0644\u0644\u0645\u0633\u0627\u0639\u062f\u0629 \u0641\u064a \u062e\u0641\u0636 \u0627\u0644\u0648\u0632\u0646.
\n\u0648\u0641\u064a \u062f\u0631\u0627\u0633\u0629 \u0623\u062e\u0631\u0649 \u0623\u0638\u0647\u0631\u062a \u0641\u0626\u0631\u0627\u0646 \u062a\u063a\u0630\u062a \u0639\u0644\u064a\u0647 15 \u0623\u0633\u0628\u0648\u0639\u0627\u064b \u0642\u062f\u0631\u0629 \u062a\u062d\u0645\u0644 \u0623\u0643\u0628\u0631 \u0639\u0644\u0649 \u062c\u0647\u0627\u0632 \u0627\u0644\u0645\u0634\u064a \u0645\u0646 \u0627\u0644\u0636\u0627\u0628\u0637\u0629\u060c \u062f\u0639\u0645\u0627\u064b \u0644\u062f\u0648\u0631\u0647 \u0641\u064a \u062a\u0646\u0634\u064a\u0637 SIRT1 (35).
\n\u0647\u0644 \u062a\u0646\u0637\u0628\u0642 \u0627\u0644\u062a\u0623\u062b\u064a\u0631\u0627\u062a \u0639\u0644\u0649 \u0627\u0644\u0628\u0634\u0631\u061f \u064a\u0644\u0632\u0645 \u0628\u062d\u062b \u0645\u0633\u062a\u0642\u0628\u0644\u064a \u0644\u0644\u0625\u062c\u0627\u0628\u0629.<\/p>\n


\n\u062c\u0631\u0639\u0629 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644 \u0648\u0633\u0644\u0627\u0645\u062a\u0647 \u0648\u062a\u0648\u0627\u0641\u0631\u0647
\n<\/u><\/strong><\/h2>\n

\u0644\u0623\u0646 \u0645\u0639\u0638\u0645 \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0645\u062e\u0628\u0631\u064a\u0629 \u0623\u0648 \u062d\u064a\u0648\u0627\u0646\u064a\u0629\u060c \u064a\u0635\u0639\u0628 \u062a\u062d\u062f\u064a\u062f \u062c\u0631\u0639\u0629 \u0645\u0646\u0627\u0633\u0628\u0629 \u0644\u0644\u0625\u0646\u0633\u0627\u0646. \u0648\u0642\u0627\u0644 \u0627\u0644\u0628\u0627\u062d\u062b \u0627\u0644\u062f\u0643\u062a\u0648\u0631 Johan Auwerx \u0641\u064a \u0645\u0642\u0627\u0628\u0644\u0629 (36) \u0625\u0646\u0647 \u064a\u062a\u0646\u0627\u0648\u0644 \u0634\u062e\u0635\u064a\u0627\u064b 40 \u0645\u0644\u063a \u064a\u0648\u0645\u064a\u0627\u064b. \u0648\u064a\u0646\u0642\u0644 \u0627\u0644\u0645\u0635\u062f\u0631 \u0639\u062f\u0645 \u0645\u0644\u0627\u062d\u0638\u0629 \u0622\u062b\u0627\u0631 \u062c\u0627\u0646\u0628\u064a\u0629 \u0628\u0634\u0631\u064a\u0629 \u062d\u062a\u0649 5,000 \u0645\u0644\u063a (37)\u060c \u0648\u0645\u0644\u0641 \u0633\u0644\u0627\u0645\u0629 \u0645\u0634\u0627\u0628\u0647\u0627\u064b \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u0627\u0646\u064a\u0629.<\/p>\n


\n\u062a\u0634\u0645\u0644 \u0627\u0644\u0645\u0635\u0627\u062f\u0631 \u0627\u0644\u063a\u0630\u0627\u0626\u064a\u0629 \u0627\u0644\u063a\u0646\u064a\u0629 \u0628\u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644:
\n<\/strong><\/h2>\n

\u2022 \u0627\u0644\u0646\u0628\u064a\u0630 \u0627\u0644\u0623\u062d\u0645\u0631 (5 \u0643\u0624\u0648\u0633): \u0646\u062d\u0648 0.30\u20131.07 \u0645\u0644\u063a.
\n\u2022 \u0643\u0648\u0628 \u0641\u0648\u0644 \u0633\u0648\u062f\u0627\u0646\u064a: \u0646\u062d\u0648 0.01\u20130.26 \u0645\u0644\u063a.
\n\u2022 \u0643\u0648\u0628 \u0639\u0646\u0628 \u0623\u062d\u0645\u0631: \u0646\u062d\u0648 0.24\u20131.25 \u0645\u0644\u063a.<\/p>\n


\n\u0627\u0644\u0627\u0633\u062a\u0646\u062a\u0627\u062c\u0627\u062a:
\n<\/u><\/strong><\/h2>\n

\u064a\u0644\u0632\u0645 \u0645\u0632\u064a\u062f \u0645\u0646 \u0627\u0644\u0628\u062d\u062b\u060c \u062e\u0627\u0635\u0629 \u0644\u062f\u0649 \u0627\u0644\u0628\u0634\u0631\u060c \u062d\u0648\u0644 \u0646\u0634\u0627\u0637 \u0627\u0644\u0631\u064a\u0633\u0641\u064a\u0631\u0627\u062a\u0631\u0648\u0644. \u0648\u062d\u062a\u0649 \u0630\u0644\u0643 \u0627\u0644\u062d\u064a\u0646 \u0623\u0638\u0647\u0631 \u0641\u0648\u0627\u0626\u062f \u0635\u062d\u064a\u0629 \u0645\u062d\u062a\u0645\u0644\u0629 \u0639\u062f\u064a\u062f\u0629\u060c \u0648\u064a\u0639\u062a\u0628\u0631\u0647 \u0627\u0644\u0645\u0635\u062f\u0631 \u0622\u0645\u0646\u0627\u064b \u0644\u0645\u0646 \u064a\u0631\u063a\u0628 \u0641\u064a \u062a\u062c\u0631\u0628\u062a\u0647.<\/p>\n

\n

References:<\/strong><\/p>\n

1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clin Biochem 1997;30:91\u2013113.<\/p>\n

2. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.<\/p>\n

3. Labinskyy N, Csiszar A, Veress G, Stef G, Pacher P, Oroszi G, Wu J, Ungvari Z. Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen. Current medicinal chemistry 2006; 13(9):989-96.<\/p>\n

4. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.<\/p>\n

5. Wallerath T, Deckert G, Ternes T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002; 106(13):1652-1658.<\/p>\n

6. Fukao H, Ijiri Y, Miura M, et al. Effect of trans-resveratrol on the thrombogenicity and atherogenicity in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Blood Coagul Fibrinolysis 2004; 15(6):441-446.<\/p>\n

7. Wang Z, Zou J, Huang Y, Cao K, Xu Y, Wu JM. Effect of resveratrol on platelet aggregation in vivo and in vitro. Chin Med J 2002; 115(3):378-380.<\/p>\n

8. Bradamante S, Barenghi L, Villa A. Cardiovascular protective effects of resveratrol. Cardiovasc Drug Rev 2004; 22(3):169-188.<\/p>\n

9. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.<\/p>\n

10. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: A molecule whose time has come? And gone? Clin Biochem 1997;30:91\u2013113.<\/p>\n

11. Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997; 275:218-20<\/p>\n

12. Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004; 23:9247-58.<\/p>\n

13. Murias M, Handler N, Erker T, et al. Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship. Bioorg Med Chem 2004; 12:5571-8.<\/p>\n

14. Holmes-McNary M, Baldwin AS, Jr. Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase. Cancer Res 2000; 60:3477-83.<\/p>\n

15. Hwang D, Fischer NH, Jang BC, et al. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochem Biophys Res Commun 1996; 226:810-8.<\/p>\n

16. Pervaiz S. Resveratrol: from grapevines to mammalian biology. FASEB J 2003;17:1975-85.<\/p>\n

17. Elmali N, Baysal O, Harma A, et al. Effects of resveratrol in inflammatory arthritis. Inflammation 2007; 30(1-2):1-6.<\/p>\n

18. Higdon J. Resveratrol. Micronutrient Information Center: Linus Pauling Institute; 2005. Retrieved June 13, 2007 from http:\/\/lpi.oregonstate.edu\/infocenter\/phytochemicals\/resveratrol\/index.html#intro.<\/p>\n

19. Banerjee S, Bueso-Ramos C, Aggarwal BB. Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9. Cancer Res 2002; 62(17):4945-4954.<\/p>\n

20. Li ZG, Hong T, Shimada Y, et al. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 2002; 23(9):1531-1536.<\/p>\n

21. Tessitore L, Davit A, Sarotto I, Caderni G. Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. Carcinogenesis 2000; 21(8):1619-1622.<\/p>\n

22. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.<\/p>\n

23. Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nature reviews. Drug discovery 2006; 5(6):493-506.<\/p>\n

24. Palamara AT, Nencioini L, Aquilano K, et al. Inhibition of influenza A virus replication by resveratrol. Journal of Infectious Diseases 2005; 191(10):1719-29.<\/p>\n

25. Faith SA, Sweet TJ, Bailey E, Booth T, Docherty JJ. Resveratrol suppresses nuclear factor-kappaB in herpes simplex virus infected cells. Antiviral research 2006; 72(3):242-51.<\/p>\n

26. Heredia A, Davis C, Redfield R. Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol. J Acquir Immune Defic Syndr. 2000; 25(3):246-55.<\/p>\n

27. Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. \u201cSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan\u201d. Nature. 2003; 425(6954):191-6<\/p>\n

28. Wood JG, Rogina B, Lavu1 S, Howitz K, Helfand SL, Tatar M, Sinclair D. \u201cSirtuin activators mimic caloric restriction and delay ageing in metazoans\u201d. Nature 2004; 430(7000):686-689.<\/p>\n

29. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A \u201cResveratrol Prolongs Lifespan and Retards the Onset of Age-Related Markers in a Short-Lived Vertebrate.\u201d Current Biology 2006; 16 (3):296-300.<\/p>\n

30. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444(7117):337-42.<\/p>\n

31. Hsu C-L, Yen G-Ch. Induction of cell apoptosis in 3T3-L1 pre-adipocytes by flavonoids is associated with their antioxidant activity. Molecular nutrition & food research 2006; 50(11):1072-9.<\/p>\n

32. Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado de Oliveira R, Leid M, McBurney MW, Guartente L. Sirt promotes fat mobilization in white adipocytes by repressing PPAR-\u03b3. Nature 2004; 429:771-76.
\n33. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127(6):1109-22.<\/p>\n

34. Koo S-H, Montminy M. In vino veritas: a tale of two sirt1s? Cell 2006; 127(6):1091-3.<\/p>\n

35. Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P, Geny B, Laakso M, Puigserver P, Auwerx J. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1\u03b1. Cell 2006; 127(6):1109-1122.<\/p>\n

36. Wade, Nicholas. Red Wine Ingredient Increases Endurance, Study Shows. New York Times;November 16 2006.<\/p>\n

37. Boocook DJ, et al. Proc Amer Assoc Cancer Res 2006;47:Abstract #5741<\/p>\n

38. Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 2002; 132(2):257-260<\/p>\n","protected":false},"excerpt":{"rendered":"

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