{"id":16661,"date":"2024-06-23T10:42:00","date_gmt":"2024-06-23T07:42:00","guid":{"rendered":"https:\/\/marshal.co.il\/?p=16661"},"modified":"2026-10-29T00:19:19","modified_gmt":"2026-10-28T21:19:19","slug":"%d8%b9%d8%b5%d9%8a%d8%b1-%d8%a7%d9%84%d8%ac%d8%b1%d9%8a%d8%a8-%d9%81%d8%b1%d9%88%d8%aa-%d9%8a%d8%ad%d8%b3%d9%91%d9%86-%d8%a7%d9%85%d8%aa%d8%b5%d8%a7%d8%b5-coq10","status":"publish","type":"post","link":"https:\/\/marshal.co.il\/ar\/%d8%b9%d8%b5%d9%8a%d8%b1-%d8%a7%d9%84%d8%ac%d8%b1%d9%8a%d8%a8-%d9%81%d8%b1%d9%88%d8%aa-%d9%8a%d8%ad%d8%b3%d9%91%d9%86-%d8%a7%d9%85%d8%aa%d8%b5%d8%a7%d8%b5-coq10\/","title":{"rendered":"\u0639\u0635\u064a\u0631 \u0627\u0644\u062c\u0631\u064a\u0628 \u0641\u0631\u0648\u062a \u064a\u062d\u0633\u0651\u0646 \u0627\u0645\u062a\u0635\u0627\u0635 CoQ10"},"content":{"rendered":"

Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2\u201d in the May 15, 2010 issue of Food Chemistry\n<\/p>\n

CoQ10<\/span>
\n\u0627\u0643\u062a\u064f\u0634\u0641 \u0623\u0648\u0644 \u0645\u0631\u0629 \u0639\u0627\u0645 1957\u060c \u0648\u0645\u0646\u0630 \u0630\u0644\u0643 \u0627\u0644\u062d\u064a\u0646 \u062a\u062a\u0631\u0627\u0643\u0645 \u0627\u0644\u0623\u062f\u0644\u0629 \u0627\u0644\u0639\u0644\u0645\u064a\u0629 \u062d\u0648\u0644 \u0623\u0647\u0645\u064a\u062a\u0647 \u0644\u0644\u0635\u062d\u0629. \u0648\u064a\u0648\u062c\u062f \u0641\u064a \u0643\u0644 \u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062c\u0633\u0645\u060c \u062e\u0635\u0648\u0635\u064b\u0627 \u0627\u0644\u0642\u0644\u0628 \u0648\u0627\u0644\u0643\u0628\u062f \u0648\u0627\u0644\u0643\u0644\u0649 \u0648\u0627\u0644\u0628\u0646\u0643\u0631\u064a\u0627\u0633. \u0648\u062a\u0634\u0645\u0644 \u0623\u062f\u0648\u0627\u0631\u0647 \u062f\u0639\u0645 \u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u062a\u0647\u0627\u0628 \u0635\u062d\u064a\u0629\u060c \u0648\u0648\u0638\u064a\u0641\u0629 \u0630\u0647\u0646\u064a\u0629 \u0637\u0628\u064a\u0639\u064a\u0629\u060c \u0648\u0635\u062d\u0629 \u0627\u0644\u0642\u0644\u0628 \u0648\u0633\u0643\u0631 \u062f\u0645 \u0637\u0628\u064a\u0639\u064a (2\u20137). \u0648\u0647\u0648 \u0623\u064a\u0636\u064b\u0627 \u0645\u0636\u0627\u062f \u0623\u0643\u0633\u062f\u0629 \u0642\u0648\u064a \u0648\u0644\u0647 \u062f\u0648\u0631 \u0645\u0647\u0645 \u0641\u064a \u0625\u0646\u062a\u0627\u062c \u0637\u0627\u0642\u0629 \u0627\u0644\u062e\u0644\u064a\u0629.\n<\/div>\n
<\/div>\n
\n\u0631\u063a\u0645 \u0647\u0630\u0647 \u0627\u0644\u0641\u0648\u0627\u0626\u062f \u0627\u0644\u0635\u062d\u064a\u0629\u060c \u0645\u0646 \u0623\u0628\u0631\u0632 \u0645\u0634\u0643\u0644\u0627\u062a
\nCoQ10<\/span>
\n\u0627\u0646\u062e\u0641\u0627\u0636 \u062a\u0648\u0627\u0641\u0631\u0647 \u0627\u0644\u062d\u064a\u0648\u064a\u060c \u0623\u064a \u0636\u0639\u0641 \u0627\u0645\u062a\u0635\u0627\u0635\u0647 \u0645\u0639\u0648\u064a\u064b\u0627 (8). \u0648\u0647\u0630\u0627 \u064a\u062a\u0637\u0644\u0628 \u0627\u0644\u062c\u0645\u0639 \u0628\u064a\u0646 \u0645\u0643\u0645\u0651\u0644\u0627\u062a
\nCoQ10<\/span>
\n\u0648\u0645\u0643\u0648\u0651\u0646\u0627\u062a \u062f\u0647\u0646\u064a\u0629 \u0644\u062f\u0639\u0645 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 (9). \u0648\u0648\u062c\u062f\u062a \u062f\u0631\u0627\u0633\u0629 \u0645\u062e\u0628\u0631\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u0623\u0646 \u0639\u0635\u064a\u0631 \u0627\u0644\u062c\u0631\u064a\u0628 \u0641\u0631\u0648\u062a \u0642\u062f \u064a\u062d\u0633\u0651\u0646 \u0627\u0645\u062a\u0635\u0627\u0635
\nCoQ10<\/span><\/div>\n
\n\u0648\u062c\u062f \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u062d\u0636\u0651\u0646\u0629 \u0633\u0627\u0639\u062a\u064a\u0646 \u0641\u064a \u0645\u062d\u0644\u0648\u0644 \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 1% \u0645\u0646 \u0639\u0635\u064a\u0631 \u0627\u0644\u062c\u0631\u064a\u0628 \u0641\u0631\u0648\u062a \u0627\u0645\u062a\u0635\u0651\u062a \u0645\u0646 \u0627\u0644\u0645\u0643\u0648\u0651\u0646 \u0623\u0643\u062b\u0631 \u0628\u0646\u0633\u0628\u0629 50% \u0645\u0646 \u062e\u0644\u0627\u064a\u0627 \u0645\u062c\u0645\u0648\u0639\u0629 \u0627\u0644\u063a\u0641\u0644. \u0648\u0628\u0630\u0644\u0643 \u0632\u0627\u062f \u0627\u0644\u0639\u0635\u064a\u0631 \u0627\u0644\u0627\u0645\u062a\u0635\u0627\u0635 \u0628\u0635\u0648\u0631\u0629 \u0645\u0639\u0646\u0648\u064a\u0629.\n<\/div>\n
\n\u0627\u0642\u062a\u0631\u062d \u0627\u0644\u0628\u0627\u062d\u062b\u0648\u0646 \u0623\u0646 \u0627\u0644\u0639\u0635\u064a\u0631 \u064a\u0632\u064a\u062f \u0627\u0645\u062a\u0635\u0627\u0635
\nCoQ10<\/span>
\n\u0628\u062e\u0641\u0636 \u0646\u0634\u0627\u0637 \u0628\u0631\u0648\u062a\u064a\u0646
\nP-glycoprotein<\/span>
\n\u060c \u0627\u0644\u0630\u064a \u064a\u062a\u062d\u0643\u0651\u0645 \u0645\u0628\u0627\u0634\u0631\u0629\u064b \u0641\u064a \u0627\u0645\u062a\u0635\u0627\u0635
\nCoQ10<\/span>
\n\u0625\u0644\u0649 \u0627\u0644\u062e\u0644\u0627\u064a\u0627.\n<\/div>\n
\n\u064a\u0624\u062b\u0631 \u0639\u0635\u064a\u0631 \u0627\u0644\u062c\u0631\u064a\u0628 \u0641\u0631\u0648\u062a \u0639\u0644\u0649 \u0627\u0645\u062a\u0635\u0627\u0635 \u0623\u062f\u0648\u064a\u0629 \u0645\u0648\u0635\u0648\u0641\u0629\u060c \u0645\u0646\u0647\u0627 \u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0636\u063a\u0637 \u0648\u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0643\u0648\u0644\u064a\u0633\u062a\u0631\u0648\u0644 \u0648\u0646\u0638\u0645 \u0627\u0644\u0642\u0644\u0628\u060c \u0645\u0645\u0627 \u064a\u062a\u0637\u0644\u0628 \u0627\u0644\u0648\u0639\u064a \u0648\u0627\u0644\u062a\u0635\u0631\u0641 \u0648\u0641\u0642\u064b\u0627 \u0644\u0630\u0644\u0643. \u0647\u0644 \u062a\u062a\u0646\u0627\u0648\u0644\u0648\u0646 \u0623\u062f\u0648\u064a\u0629 \u0645\u0648\u0635\u0648\u0641\u0629\u061f \u0623\u062e\u0628\u0631\u0648\u0627 \u0627\u0644\u0637\u0628\u064a\u0628 \u0627\u0644\u0645\u0639\u0627\u0644\u062c \u0625\u0630\u0627 \u0631\u063a\u0628\u062a\u0645 \u0641\u064a \u0625\u0636\u0627\u0641\u0629 \u0639\u0635\u064a\u0631 \u0627\u0644\u062c\u0631\u064a\u0628 \u0641\u0631\u0648\u062a \u0625\u0644\u0649 \u063a\u0630\u0627\u0626\u0643\u0645.<\/p>\n
References:<\/strong><\/div>\n
1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u201cQuestions and answers about Coenzyme Q10\u201d posted on the National Cancer Institute Website\u00a0http:\/\/www.cancer.gov\/cancertopics\/pdq\/cam\/coenzymeQ10\/Patient\/page2<\/a>
\n2. Wang, X.L., et al., Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons.\u00a0Am J Clin Nutr<\/em>, 2004. 80(3): p. 649-55
\n3. Ishrat T. \u00a0Coenzyme Q10 modulates cognitive impairment against intracerebroventricular injection of streptozotocin in rats. \u00a0Printed online in\u00a0Behavioural Brain Research<\/em>\u00a0doi:10.1016\/j.bbr.2006.03.009
\n4. Hargreaves IP. \u00a0The coenzyme Q10 status of the brain regions of Parkinson\u2019s disease patients. \u00a0Neuroscience Letters<\/em>\u00a0447 (2008) 17\u201319
\n5. Pothmann, R. \u00a0Migraine Prevention in Children and Adolescents: Results of an Open Study With a Special Butterbur Root Extract. \u00a0Headache<\/em>\u00a02005; 45(3): 196-203
\n6. Wisloff, U., S. M. Najjar, et al. (2005). “Cardiovascular risk factors emerge after artificial selection for low aerobic capacity.”\u00a0Science<\/em>\u00a0307(5708): 418-20
\n7. Petersen, K. F., D. Befroy, et al. (2003). “Mitochondrial dysfunction in the elderly: possible role in insulin resistance.”\u00a0Science<\/em>\u00a0300(5622): 1140-2
\n8. Y. Zhang, F. Aberg, E.L. Appelkvist, G. Dallner and L. Ernster, Uptake of dietary coenzyme Q supplement is limited in rats,\u00a0Journal of Nutrition<\/em>\u00a0125 (1995), pp. 446\u2013453
\n9. \u201cCoQ10 Emulsions Boost Bioavailability\u201d posted on Nutraingredients.com \u2013 April 8, \u00a02008\u00a0http:\/\/www.nutraingredients.com\/Research\/CoQ10-emulsions-boost-bioavailability-study<\/a>
\n10. Itagaki S. \u00a0Grapefruit juice enhance the uptake of coenzyme Q10 in the human intestinal cell-line Caco-2. \u00a0Food Chemistry<\/em>\u00a02010; 120(2): 552-555
\n11. A. Dahan and G.L. Amidon, Grapefruit juice and its constituents augment colchicine intestinal absorption: Potential hazardous interaction and the role of p-glycoprotein,\u00a0Pharmaceutical Research<\/em>\u00a026 (2009), pp. 883\u2013892
\n12. Itagaki S. \u00a0Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein,\u00a0Journal of Agricultural and Food Chemistry<\/em>\u00a056 (2008), pp. 6923\u20136927<\/span><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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